Aggregate sizes were determined using image processing techniques, while apparent viscosity was measured using optical viscometry. RBC aggregate sizes were quantified in controlled and measurable shear rate environments for 5, 10 and 15% hematocrit. Experiments were performed using a micro particle image velocimetry (μPIV) system for shear rate measurements, coupled with a high-speed camera for flow visualization. These microchannels were fabricated using standard photolithography methods. Suspensions of human blood were flowed and observed in vitro in poly-di-methyl-siloxane (PDMS) microchannels to characterize RBC aggregates. The main objective of this work is to quantify and characterize RBC aggregates in order to enhance the current understanding of the non-Newtonian behaviour of blood in microcirculation. The theory and mechanics behind aggregation are, however, not yet completely understood. Remarkably RBCs deform and bridge together to form aggregates under very low shear rates. Red blood cells (RBCs) are the most abundant cells in human blood.
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